Heard it here first folks!
The two policies that I feel are most likely to actually change in the Obama administration:
1. Drug policy - I think the US is really ready to look at how are current drug policies are harming our criminal justice, immigration and pubic health systems not to mention the racial and class hypocrisies it embodies.
2. Relations with Cuba - I mean come on already, the Soviet Union ended in 1991 and even Castro isn't exactly what he used to be.
Guns in the holsters.